Main Topics

This two-day conference will cover the topic of the biophysics of “protein misfolding”, ranging from: i) the mechanism of protein folding/misfolding; ii) the understanding of the physical basis for the pathological aggregation of peptides and proteins; iii) the formation, propagation, and biology of prions and prion-like proteins.

In particular, the meeting will be divided into the following sessions:

  • Structure of amyloids and prions
  • Pathways of amyloid and prion formation
  • Prevention strategies
  • Self-propagation/Prions

The program will include both Plenary Lectures as well as 20 min oral presentations chosen from abstracts and posters. A poster session will also constitute an important part of the scientific program.

 Amyloids and Prion Final Program (.pdf) Scientific Programs and Abstracts

Conference Schedule

Sunday, May 25th Room Compagna

    • 9:00 – 9:45 – Participant registration
    • 9:45 – 10:00 – Introduction & welcome

Opening Lecture. Chair: William F. DeGrado

    • 10:00 – 10:50 – PL-1: Stanley Prusiner
      University of California, USA
      “Prions Causing Neurodegeneration: A Unifying Etiology and the Quest for Therapeutics”
    • 10:50 – 11:30 – Coffee break
Session 1: Structural Studies. Chair: Detlev Riesner.
    • 11:30 – 12:10 – PL- 2: Fabrizio Chiti
      University of Florence, Italy
      “The structural determinants of protein oligomer toxicity”
    • 12:10 – 12:30 – OC-1: Stefano Ricagno
      University of Milano, Italy
      “D76N Beta-2 microglobulin, an amyloidogenic and pathologic mutant (clues on the native and on the fibrillar states)”
    • 12:30 – 12:50 – OC-2: Holger Wille
      University of Alberta, Edmonton, Canada
      “A hybrid approach towards the structure of PrPSc”
    • 12:50 – 13:10 – Exhibitor Talk (by Shimadzu)
      Roberto Castangia
      “Analysis and characterisation of Human Glycoproteins using MALDI TOF Mass Spectrometry”
    • 13:10 – 14:30 – Lunch (Sponsored by Shimadzu)
Session 2: Structures, dynamics and interactions by NMR. Chair: Koichi Kato
  • 14:30 – 15:10 – PL-3: Astrid Gräslund
    Stockholm University, Sweden
    “Biophysical studies of the amyloid  peptide involved in Alzheimer´s disease: molecular interactions, secondary structure conversions and aggrega”
  • 15:10 – 15:30 – OC-3: Giuliana Fusco
    University of Cambridge, United Kingdom
    “Unveiling the Nature of α-Synuclein in its Membrane-Bound State by Solid-State and Solution NMR”
  • 15:30 – 15:50 – OC-4: Alfonso De Simone
    Imperial College London, United Kingdom
    “Order and disorder in amyloid formation”
  • 15:50 – 16:40 – Poster Session and Coffee break
Session 3: Spectroscopies in fibrillation pathway. Chair: Gaetano Irace
  • 16:40 – 17:20 – PL-4: Daniel P. Raleigh
    Stony Brook University, USA
    “Biophysical studies of the amyloid beta peptide involved in Alzheimer´s disease: molecular interactions, secondary structure conversions and aggregation”
  • 17:20 – 17:40 – OC-5: Andreas Barth
    Stockholm University, Sweden
    “Computational Infrared Spectroscopy of Proteins – Implications for the Spectrum of Amyloids”
  • 17.40 – 18:00 – OC-6: Mauro Manno
    National Research Council of Italy (CNR), Palermo, Italy
    “Electrostatics promotes molecular crowding and selects the fibrillation pathway in fibril-forming protein solutions”
  • 20:30 – 23:00 – Gala Dinner at Tennis Club Napoli

Monday, May 26th Room Compagna

Session 4: Aggregation Pathway. Chairs: Giuseppe Graziano and Jesus R. Requena

  • 9:00 – 9:40 – PL-5: Tuomas Knowles
    University of Cambridge, United Kingdom
    “Biophysical insights into protein aggregation”
  • 9:40 – 10:00 – OC-7: Clara Iannuzzi
    Seconda Università di Napoli, Naples, Italy
    “Insights into the molecular mechanism of glycation-stimulated protein aggregation”
  • 10:00 – 10:20 – OC-8: Sanjeevi Sivasankar
    Iowa State University, Ames, United States
    “Resolving prion protein aggregation at the single molecule level”
  • 10:20 – 10:40 – OC-9: Alessandro Marrone
    National Research Council of Italy (CNR), Palermo, Italy
    “Investigation of the molecular electrostatic potential similarity in PrP model systems”
  • 10:40 – 11:10 Coffee break
  • 11:10 – 11:50 – PL-6: Roland Riek
    ETH Zürich, Switzerland
    “Structure-Activity Relationship of protein aggregates in health and disease”
  • 11:50 – 12:10 – OC-10: Maria Andreasen
    Interdisciplinary Nanoscience Center, Aarhus University, Aarhus, Denmark
    ““Cytotoxic α-synuclein oligomers and their role in aggregation”
  • 12:10 – 12:40 –  A pioneer in biotechnology talk (by CreAgri)
    Roberto Crea
    “Biotechnology, Brain and the Mediterranean Diet”
  • 12:40 – 14:00 Lunch (Sponsored by CreAgri)

Session 5: Mechanism of Disease, Prevention and Therapeutics. Chairs: Renata Piccoli and Vincenzo Pavone

  • 14:00 – 14:40 – PL-7: Stephen C Meredith
    The College of the University of Chicago, USA
    “Brain Seeded -Amyoid Fibrils”
  • 14:40 – 15.00 – OC-11: David W. Colby
    University of Delaware, Newark, United States
    “Detection of pathological tau conformations in CSF of patients with neurodegenerative diseases”
  • 15:00 – 15:40 PL-8: James Shorter
    University of Pennsylvania, USA
    “Potentiated protein disaggregases to combat neurodegeneration”
  • 15:40 – 16:00 OC-12: Annalisa Pastore
    King’s College of London, United Kingdom
    “Protein-protein interactions as a strategy towards protein-specific drug design”
  • 16:00 – 16:20 OC-13: Andriy Kovalenko
    National Institute for Nanotechnology, University of Alberta, Edmonton, Canada
    “Molecular recognition and optimization of translocation of antiprion therapeutic agents from molecular theory of solvation”
  • 16:20 – 16:40 OC-14: Jan Bieschke
    Washington University in St Louis, United States
    “From molecular mechanisms to intervention strategies: Stabilizing fibrils to inhibit prion replication”
  • 16:40 – 17:00 Closing remarks